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Research

Parallel cut research time and cost in half with GPT‑6 Astra

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GPT‑6 Astra allowed Parallel’s agents to research and synthesize labor-market data in half the time and at half the cost vs. prior models. Parallel⁠ builds developer infrastructure for AI agents that do knowledge work over the web. Its tools support everything from web grounding for voice agents to research for financial institutions and legal customers, combining frontier models with web search. For Parallel’s longest-running research tasks, getting a high-quality answer typically meant using a bigger model with extended

OpenAI · 22 Sep 2026 · 14:00 CESTRead story →Original ↗
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How a researcher uses Codex and ChatGPT to search for new antimicrobial molecules

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César de la Fuente and his lab probe the genomes of living and extinct organisms for molecules that could help fight drug-resistant infections. Drug-resistant microbes including bacteria, fungi, parasites, and viruses are a growing global threat. About five million deaths in 2021 were associated⁠ with bacterial antimicrobial resistance—an annual toll projected to roughly double by 2050. It can take years to find molecules with the potential to become antimicrobials. Researchers are using AI to accelerate this early stage of discovery. “Antimicrobial resistance is one of the greatest existential threats to…

OpenAI · 10 Sep 2026 · 18:00 CESTRead story →Original ↗
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Research

How enabling two settings tripled our scores on the ARC-AGI-3 benchmark

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A sped-up video of GPT‑5.6 Sol attempting to solve puzzles in the ARC-AGI-3 benchmark, with the official harness (left) and our Responses API harness (right), which retains reasoning and enables compaction. On the leaderboard for this game⁠, no frontier model solves any level beyond the first. With our harness, GPT‑5.6 Sol solves all six. When we first saw GPT‑5.6 Sol’s low scores on the ARC-AGI-3⁠ benchmark, we were puzzled. GPT‑5.6 Sol has solved longstanding open problems in mathematics like the cycle double cover conjecture⁠ and beaten games like Pokémon FireRed.…

OpenAI · 29 Jul 2026 · 17:00 CESTRead story →Original ↗
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A near-autonomous AI chemist improves a challenging reaction in medicinal chemistry

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With Molecule.one’s Maria, GPT‑5.4 found a surprising additive boosting Chan-Lam Coupling yields for over 80% of tested substrates. OpenAI’s work in science is motivated by a simple belief: advanced AI can become a powerful partner for scientists, helping them explore more ideas, connect distant concepts, design better experiments, and accelerate discoveries that benefit humanity. We have already shared early examples of models contributing to novel results in mathematics, including work on the unit distance problem⁠, in theoretical physics, through a new result on gluon amplitudes⁠, and in biology, where GPT‑5…

OpenAI · 17 Jun 2026 · 12:00 CESTRead story →Original ↗
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How an astrophysicist uses Codex to help simulate black holes

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Codex helps Chi-kwan Chan to refine and test algorithms that simulate the movement of electrons and ions around a black hole. The gravity around a black hole is so extreme that nothing, not even light, can escape once it gets close enough. Astrophysicists like Chi-kwan Chan study black holes with computer simulations and observations. But current algorithms and computing power limit how realistic those simulations can be. With Codex, Chan—a researcher at the University of Arizona and Steward Observatory—is tackling this problem. Black holes are among the best places to…

OpenAI · 11 Jun 2026 · 02:00 CESTRead story →Original ↗
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